Post-effective amendment to a registration statement that is not immediately effective upon filing

Description of the Business and Liquidity (Details Narrative)

v3.7.0.1
Description of the Business and Liquidity (Details Narrative) - USD ($)
 3 Months Ended 12 Months Ended
Aug. 31, 2016
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Cumulative net loss   $ (95,524,502)   $ (93,868,764) $ (85,726,580)
Net cash flows from operating activities   $ (1,346,177) $ (1,608,561) (5,820,043) (8,637,734)
Proceeds from issuance of private placement       $ 5,800,000 $ 8,600,000
Brainlab Senior Secured Note Payable [Member]          
Maturity date   Dec. 31, 2018   Dec. 31, 2018 Apr. 30, 2016
Debt face amount   $ 2,000,000   $ 2,000,000 $ 5,000,000
September 2016 Private Placement [Member]          
Proceeds from issuance of private placement   3,800,000   3,800,000  
Debt face amount   1,750,000   1,750,000  
September 2016 Private Placement [Member] | Secured Notes 2014 [Member]          
Conversion of private placement equity into debt $ 1,750,000        
Description of unit
Each unit consisting of one share of the Company’s common stock and one warrant to purchase 0.90 share of the Company’s common stock, based on the offering price per unit in the 2016 PIPE.
       
December 2015 Private Placement [Member]          
Proceeds from issuance of private placement   4,700,000   4,700,000  
December 2014 Private Placement [Member]          
Proceeds from issuance of private placement   9,400,000   9,400,000  
March 2014 Private Placement [Member]          
Proceeds from issuance of private placement   $ 3,500,000   $ 3,500,000